Ferritin högt

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Often, this will be either a hematology/oncology doctor or a gastroenterologist specializing in liver conditions. Blood Reviews, 23(3), 95–104. Severely elevated ferritin levels usually warrant an evaluation by a specialist. Om den lämnas obehandlad kan järnöverskott orsaka oåterkalleliga skador på levern, hjärtat, lederna och bukspottkörteln, vilket ökar risken för allvarliga tillstånd som cirros, hjärtsvikt, diabetes och vissa former av cancer.

Hypoferritinemi: Lågt ferritin

Orsaker till hypoferritinemi

Lågt ferritin är ofta den första indikatorn på järnbrist, den vanligaste orsaken till anemi.

Here’s what you need to know.

What Is Ferritin and Why Is It Measured?

Ferritin is a protein primarily found in the liver, spleen, and bone marrow. Hemoglobin transporterar syre från lungorna till resten av kroppen. https://www.rupahealth.com/post/hemochromatosis-causes-symptoms-inheritance-and-testing

  • Cloyd, J.

    (2024, September 17). Understanding the various reasons for increased ferritin is important to grasp its significance.

    Understanding Ferritin’s Purpose

    Ferritin functions as the primary iron storage protein, found inside cells throughout the body, especially in the liver, spleen, and bone marrow. These tests include[12]:

    • Serum iron levels: a measure of the total amount of iron in the blood
    • Transferrin levels: measures the level of a protein that is responsible for iron transport
    • Total iron-binding capacity (TIBC): measures the amount of iron attached to proteins in the blood
    • C-reactive protein (CRP): a marker of inflammation
    • Genetic testing: hemochromatosis is a genetic condition that is associated with the HFE gene.

      Based on this comprehensive evaluation, your doctor may recommend further investigations to pinpoint the underlying cause. Understanding ferritin levels: what they say about your health.

      ferritin högt

      Ferritin binds iron, rendering it nontoxic.

    • Iron recycling: Ferritin helps recycle iron released through the breakdown of red blood cells.

    The normal value for ferritin levels varies based on sex and age. (n.d.). Chronic inflammatory disorders like rheumatoid arthritis or inflammatory bowel disease often lead to elevated ferritin.

    Medications like deferoxamine, deferiprone, and deferasirox may be used to remove iron.[19]

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    Key Takeaways

    • Ferritin plays a key role in iron balance
    • Low ferritin levels can be a sign of iron deficiency
    • High ferritin is associated with inflammation and iron overload
    • Untreated, high ferritin can lead to organ damage and death
    • Ferritin can be easily checked with a lab test
    • Elevated ferritin levels can be treated using several different options

    The information in this article is designed for educational purposes only and is not intended to be a substitute for informed medical advice or care.

    Elevated ferritin may signal conditions like hepatitis, fatty liver, or cirrhosis.

  • Certain Cancers
    Malignancies, particularly blood cancers like leukemia or lymphoma, can increase ferritin levels due to increased cell turnover or inflammation.

  • Alcohol Abuse
    Chronic alcohol consumption can damage liver tissue and elevate ferritin levels, even in the absence of excess iron.

  • Iron Supplementation or Frequent Transfusions
    Excessive iron intake, whether through supplements or repeated blood transfusions, can cause a rise in stored iron and therefore ferritin.

    • Symptoms That May Accompany High Ferritin

    In many cases, high ferritin is found incidentally through routine lab work.

    Journal of Clinical Medicine, 10(9), 2008. British journal of haematology, 175(5), 759–770. Haemochromatosis. Sometimes, an ultrasound or MRI may be necessary.

    How Providers Interpret Lab Results

    Lab tests should be interpreted with caution and with the assistance of a healthcare provider. Your doctor will consider your ferritin level in the context of your overall health, including symptoms, medical history, and other relevant blood tests.

    Additional tests may include a full iron panel, inflammatory markers like C-reactive protein, and liver function tests.

    https://doi.org/10.1093/mtomcs/mfab021

  • Rombout-Sestrienkova, E., van Kraaij, M. G., & Koek, G. H. (2016). It acts as an iron reserve, releasing iron into the bloodstream when the body needs it for functions like:

    • Red blood cell production

    • Oxygen transport

    • DNA synthesis

    • Immune response

    A ferritin blood test is often ordered when doctors suspect iron deficiency or iron overload, or when they want to understand more about unexplained fatigue, weakness, or chronic inflammation.

    Normal ferritin levels vary slightly between laboratories, but in general:

    • Men: 30–400 ng/mL

    • Women: 15–150 ng/mL

    • Children: Values depend on age

    What Causes High Ferritin Levels?

    While high ferritin may sometimes indicate too much iron, it can also be a marker of inflammation or liver dysfunction.